ABSTRACT
Introduction: Anti secretory drugs, antimicrobials and bismuth salts are used with variable success to erradicate helicobacter pylori. Aim: To assess the effectiveness and rates of reinfection of 2 therapeutic modalities H pylori infection in adult patients with duodenal ulcer or non ulcer dyspepsia. Methods: during upper gastrointestinal endoscopy, 5 antral and 2 fundic biopsies were obtained and sent for microbiological and anatomopathological study. Patients infected with Helicobacter pylori were randomly assigned to receive during 2 weeks omeprazole 20 mg od plus amoxicillin 500 mg tid (group A) or bismuth subsalicylate 260 mg bid, metronidazole 250 mg tid and amoxicillin 500 mg tid (group B). A new endoscopy with antral and fundic biopsies was performed to all patients four weeks after discontinuing treatment and six months later to those in whom H pylori was eradicated. Results: 80 patients (40 in each treatment group) completed the treatment and follow up. H pylori was eradicated in 22 patients of group A (55 percent) and 28 of group B (70 percent). Minor adverse effects were reported by 5 patients in group A (12 percent) and 11 in group B (27.5 percent). Six months later, reinfection was documented in 12 patients of group A and 8 of group B (54 percent and 30 percent of those with successful treatment respectively). Ten of 25 patients with duodenal ulcer had reinfections, but there was only one ulcer relapse. Conclusion: These 2 treatment modalities have similar results
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Omeprazole/administration & dosage , Helicobacter pylori/drug effects , Helicobacter Infections/drug therapy , Dyspepsia/drug therapy , Metronidazole/administration & dosage , Duodenal Ulcer/drug therapy , Ranitidine/administration & dosage , Gastroscopy , Dyspepsia/microbiology , Drug Administration Schedule , Duodenal Ulcer/microbiologyABSTRACT
We conducted a double blind random study on 79 patients with gastric ulcer: 39 received sucralfate, 1 g 4 times a day (Group 1) and 40 received a single evening dose of famotidine, 40 mg (Group 2). At 4 weeks, endoscopy revealed healing of the ulcer in 46% of patients in Group1 and 40% in group 2 (NS). At 8 weeks, corresponding figures were 90% and 75 (NS). All patients were able to complete treatment and minor side effects were reported from all patients, 36% with sucralfate and 28% with famotidine. Thus, sucralfate and famotidine are equally effective for therapy of gastric ulcer. The higher percentage of helaing with sucralfate observed in this study was not statistically significant
Subject(s)
Humans , Male , Female , Sucralfate/therapeutic use , Famotidine/therapeutic use , Stomach Ulcer/drug therapy , Drug Administration ScheduleABSTRACT
Diversas investigaciones han demostrado la presencia de Campylobacter pylori en mucosa gástrica humana. Presente en sujetos normales, su prevalencia alcanza elevados porcentajes en indivíduos con gastritis activa y úlcera péptica. Se discute su rol patogénico en estas afecciones y la eventual influencia que pudiera tener sobre el curso natural de la enfermedad ulcerosa